G-protein-coupled receptor

G-protein-coupled receptor
(= GPCR)
Cell surface receptors that are coupled to heterotrimeric G-proteins (GTP-binding proteins). All G-protein-coupled receptors seem to have seven membrane-spanning domains (are serpentine receptors), and have been divided into 2 subclasses: those in which the binding site is in the extracellular domain eg. receptors for glycoprotein hormones, such as thyroid stimulating hormone (TSH) and follicle-stimulating hormone (FSH), and those in which the ligand-binding site is likely to be in the plane of the 7 transmembrane domains eg. rhodopsin and receptors for small neurotransmitters and hormones eg. muscarinic acetylcholine receptor.

Dictionary of molecular biology. 2004.

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